COPY FOR PENZANCE from Mac T. Barksdale, DVM.
No doubt the Stress Packs of TF you have fed in the past have helped slow down or stop the progress of PPID. Between Dr Ramakers and my self we have probably over 200 cases improved or resolved completely. We “taper off” the pergolide and use only TF. The worst cases are the ones with the worst Thyroid abberration. We stopped treating the Thyroid deficit! It comes back to normal with only TF. The very worst case I have known took two years for the Thyroid function to return to normal. BUT IT DID COME BACK TO NORMAL! Horse’s almost never have primary Tyroid disease ! !
I wrote a paper in 2004 or 2005 detailing 23 cases of PPID recovered. I am sending you the 2008 Revision of that paper. [See article below.]
I suspect the mechanism in PPID is the inhibition or down regulation of IL-23 which is essential for the persistence of auto-immunity. My personal opinion! No one else says this. I do not believe that there is anyway that TF eliminates or causes regression of the hypertrophy [tumor enlargement] of the mid part of the Pituitary in two weeks when it has taken years for it to develop! ! Doesn’t make sense ! !
Remember this paper was written back when we were learning which tests were the best for PPID Dx. READ REPORT BELOW:
PPID Cushing’s 2005 Retrospective Study of 23 Cases
Cushing’s Management by Nutrition
Joesph C. Ramaeker,BS,DVM; William J. Hennen, PHD;
Mac T. Barksdale, DVM. 2005
Equine Cushings Syndrome is emerging to become a more common geriatric condition. A Nutritional approach appears to be an effective therapy to prolong and extend the useful life of horses. Authors address: Dr Mac Barksdale, 10151 University Bvld Bx 118, Orlando, Florida 32817 firstname.lastname@example.org
1- Introduction: The Geriatric population of horses is increasing. Many horses have transitioned from utility or work roles to that of pets or companion animals. Many have finished training the children, providing status in urban living and are retired as a part of the family. Regardless of the cause, the age of the horse population has presented a variety of geriatric challenges. Included among those is the emergence in the last decade of Equine Cushing’s Syndrome or PPID.
The Etiology of Equine Cushing’s Syndrome is Pituitary Adenoma, or Hyperplasia of the Pars Intermedia of the Pituitary Gland. The mechanism is a loss of dopaminergic innervation from the Hypothalmus that limits cell production of dopamine, resulting in hyperplasia. The resulting increased plasma ACTH elicits from the Adrenals an elevated Cortisol blood level. A Horse with a Pituitary Adenoma may produce as much as ten times the ACTH as the norm. This hyperadrenocorticism produces various complex physiologic abnormalities. The interactions of the Endocrine System may produce interruptions of body temperature control; seasonal shedding of the hair coat; appetite vagaries; Glycosuria; Polydipsia/polyuria and insulin resistance.
Initial clinical symptoms may be polydipsia with a three or four fold increase in water consumption; potbelly appearance; increased appetite with no weight gain; and a heavy hair coat that fails to shed in the spring. Many times the insidious onset of symptoms are observed by the owner but presumed to be the result of aging. Of the 23 horses in this study all were over 18 years of age with the exception of one 5 year old Thoroughbred Stallion. Most were over 20 years of age. As reported at the AAEP in December of 2002, a majority of geriatric horses develop Pituitary Adenoma. Ten of thirteen consecutive presentations at the Teaching Hospital of the Auburn University that were age 20 and over were found to have Equine Cushing’s. Laminitis may be an early presenting sign. Laminitis in the hind hooves has a high probability of being precipitated by Equine Cushing’s. Laminitis is a frequent complicating factor in advanced cases and increases the probability of a requisite poor prognosis.
Pergolide as a dopaminergic agonist and Cyproheptidine as a serotonin antagonist have been used to reduce the hypercortisolism. Specific Equine studies were few on the effectiveness of Pergolide and Cyproheptidine in the literature.
Via the aforementioned mechanism, Equine Cushing’s Syndrome is a condition characterized by excess production of the hormone Cortisol as a result of hyperplasia of the pituitary gland of the brain which produces high levels of the hormone ACTH. In other species, Cushing’s Disease is an elevation of Cortisol, whether due to hyperplasia of the Pituitary or not.
CORTISOL: A hormone produced by the adrenal gland which is released naturally during times of stress. Cortisol is ordinarily elicited by various stimuli. Such stimuli may be physiologic, as directed by the production of ACTH. Cortisol is also produced by the adrenals in neurologic interaction with the environment as in a fright or anxiety. Such excitement can also be a result of loading, transporting, racing and etc. It appears likely that performance horses would be more susceptible to hypercorticoidism. Pathologic stress, such as indigestion, infection or injury also result in an increased Cortisol level. If the Cortisol elevation is sustained for a long period of time, reduction of immune capability can result. The decrease in immune response is probably a result of the effect of Cortisol on the T-Cell function. Wound healing time is increased in hypercorticoidism, possibly from protein catabolism. In keeping with the interactions of various hormonal components other disturbances and imbalances may occur. Variations in levels of T4 Thyroid hormone were noted in the blood studies on the cases of Equine Cushing’s Syndrome reported herein.
2- Method: Equine Cushing’s Syndrome cases reported here were presented in several Veterinary Practices in California, Oregon, Arizona and Pennsylvania. Clinically most cases had a provisional diagnosis of Equine Cushing’s as a result of a history of loss of vigor; long non shedding haircoat; fat deposits in the supraorbital fossa; a cresty neck; sometimes accompanied by a loss of muscle mass. Many cases had a history of repetitive Laminitis. Reduced immune status evidenced by an increased susceptibility to illness was sometimes mentioned in the history.
The cases were determined to be Cushing’s positive by the criteria of the Cortisol Rhythm, Hyperinsulinism, or variations in T4. In a few cases, all three parameters were used. Cortisol Rhythm is the diurnal variation in circulating Cortisol. The Rhythm being established as difference between the morning fasting Cortisol level and the evening Cortisol level divided by the greater reading expressed as a percentage of excursion. The number of cases tabulated was twenty-three. Each case was selected by presenting signs and symptoms indicating a Provisional Diagnosis of Equine Cushing’s Syndrome. A rhythm of 40-50% was selected as a norm. 30-40% rhythm was classified as borderline tending toward Equine Cushing’s Syndrome. Below 30% rhythm were classified as positive for Equine Cushing’s.
Although the number of cases tabulated to this point is relatively small,[50 more case reports await tabulation to be added]. The present conclusion of the Veterinarians rporting, is that the Cortisol Rhythm quantification correlates most closely with clinical observations. [BET Labs has done over 10,000 Rhythm Tests] Consideration must be given in interpretation of the Cortisol Rhythm as the levels may be different depending upon the subject. The circumstance of stall or pasture rest or active performance and/or training may make a difference in Cortisol levels that should be taken into account. Observation of the diurnal variation helps discriminate in those cases. Of course most of the subjects in this group were not being used at the time of diagnosis. Many of them returned to active service as saddle horses. Note case 004 Hannable, 25 year old Gelding, that is now ridden 5 miles three times weekly after two years of inactivity on Pergolide.
Each case was administered per os 1500 mgm of Transfer Factor Plus daily in 4Life Research’s Equine Performance and Show product. Some of the cases treated in early 2001 received 1500 mgm Transfer Factor sans the Plus adjuvant contained in the 4Life Research Equine Performance and Show product. Ponies and horses of less than 300 Kilogram body weight received 700 mgm of Transfer Factor daily in the 4Life Research product. The length of time of daily administration of Transfer Factor was intended to be 90 days. However as these cases were in a private practice situation and under the care of their owners, it appears that the daily administration of Transfer Factor may not have been continuous. Note case 003 and case 008.
3- Results: The average morning Cortisol level was 48.86 ng compared with 20-90ng taken as a normal range. The median morning reading was 39.15 ng. The average evening Cortisol level was 41.75ng with the median found to be 23.7ng. Rhythm excursion was found from 1% to 51%.
All 23 Cases were clinically improved. In many cases the first indication of improvement was a change of attitude and behavior usually described as bright and more alert. We have records now of at least 75 more cases to be collated and added to this study.
The Shortest period of response was 78 days as quantified by the Cortisol Rhythm. Most of the cases were observed to be clinically improved in two to three weeks. However one case, 004, treated for two years with Pergolide, was sufficiently clinically improved in one week to reverse a Euthanasia decision. Other workers have noted that there is ordinarily clinical improvement noted prior to improvement in the blood value parameters.
4- Summary: Twenty-three cases were surveyed. Most exhibited nominal blood counts and blood chemistry with the exception of the T4, Insulin and Cortisol parameters. All cases were found to be clinically improved after administration of Transfer Factor[r]. Those cases complicated by Thyroid aberrations were the slowest to respond. One case required two years to reach the point where Thyroid medication was withdrawn. Some of the cases being maintained on Pergolide were tapered off medication. However some of the cases had their Pergolide regimen suddenly terminated and replaced by the Transfer Factor.
5- References and notes:
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12- Direct communication from Schott HC II, and Donaldson Mark, AAEP 2004.
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17- Schott HC II, Coursen CL, Eberhart SW, et al. The Michigan Cushing’s project, in Proceedings. 47th Annu Am Assoc Equine Pract 2001;22-24.
18- Comparison of Vitex agnus castus Extract and Pergolide in Treatment of Equine Cushing’s Syndrome Jill Beech, VMD; Mark T. Donaldson, VMD; and Sue Lindborg, BS, CAHT. AAEP PROCEEDINGS / Vol. 48 / 2002 p175-177.
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21- Jones JF,Schumacher MJ, Jeter WS, et al, Oral bovine Transfer Factor (OTF) use in the hyper-IgE syndrome. lmmunology of Transfer Factor. Academic Press; New York. 1983, pp 261-70.
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27- Whyte RI, Schon MA. Sloan H et al. Adjuvant treatment using Transfer Factor For bronchogenic carcinoma long term follow-up. Ann Thoracic Surg 1992, 53(3), 391-6.
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29- A. Basten and S.Croft Transfer Factor: Clinical usage and experimental studies. Immunological Engineering Jirsch DW(ed) MTP Press Ltd. Falcon House; Lancaster, England. 1978. pp 83-120.
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Endocrinology. 1982 Apr;110(4):1430-41. No abstract available.
PMID: 6277607 [PubMed – indexed for MEDLINE]
35: Moore JN, Steiss J, Nicholson WE, Orth DN. Related Articles, Compound via MeSH, Substance via MeSH, Books, LinkOut
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Cushing’s Management by Nutrition Tabulation of Blood Chemistry:
Morning Evening % AM PM
Cortisol Cortisol Rhythm AM T4 PM T4 Insulin Insulin
Normals 20-90ng 20-90ng 40-60% 0.9-2.8 ug/dl 4-40 iu 4-40 iu
001 Lady 28Yr ï¿½ Mare
001 3/24/01 37.6 38.2 1.60% 12.8 16.6 100 28.4
001 12/19/01 30.2 30.5 0.00% 8.3 11.3 111.4 62.3
001 1/6/03 28.3 22.8 19% 8.1 6.7 83.8 3.4
002 High Voltage 28 yr ï¿½ Geld
002 1/15/03 75.8 68.2 10% 9.9 14.7 13.7 11
003 Khazan 30Yr Arab G
003 6/26/02 46.2 44.1 4% 19.3 17 26 6.8
003 9/14/02 92.5 45.5 51% 14.4 14.7 29.2 34.9
003 9/16/02 20.2 29.9 32% 14.1 13.3 43.2 82
004 Hannable 25Yr Quarter G
004 1/26/00 31 36.3 15% 5.1 5.4 97.2 79.5
004 7/31/02 51.4 62.1 17% 13.3 13.5 10.6 21.9
005 Marka 20Yr TBx Mare
005 7/4/01 44.7 43.6 2% 7 5.6 128.3 54
005 9/7/01 69.8 34.3 51% 4.9 11 16.8 78.1
006 Tess 20Yr Arab
006 1/17/01 less than 0.2
006 10/19/01 0.4
006 6/3/02 1.5
007 Jazz 18Yr Arab Geld
007 4/17/00 31.6 51.5 39% 3.5 5.9 94 138.3
007 7/3/00 58.8 54.6 7% 25.4 25.4 217.1 273.8
007 6/20/01 3.4
007 9/8/01 53.7 37.5 30% 22.4 29.6 142.6 160.4
007 1/22/02 39 25.1 36% 23.6 25.9 100 242.9
007 3/5/02 0.9
008 Tachitts xxYr Arab Geld
008 6/1/99 24.3 18.5 24% 11.6 9.9 127.9 132.7
008 8/10/99 14.2 22.6 37%
008 8/10/99 14.8 22 37%
008 12/1/99 25.8 33.6 23% 5.3 7.4 142.8 110.2
008 10/18/00 39.8 45.6 13% 17 16.1 110.3 65.2
008 11/04/00 29.2 23.2 20% 5.5 10.1 75.4 120.5
009 Rico 25Yr Quarter
009 11/20/00 55.7 62 10% 31.6 31.5 12.1 2.5
010 Sterrschimmer xxYr ?
010 10/18/00 59.4 42.7 28% 20.5 18.1 67.5 30.3
011 Pajarro 25 Yr Mare
011 1/19/01 51.8 66.9 22% 22.3 19.8 31 43.2
011 2/22/01 62.6 56 10.50% 28.4 42.7 40.3 33.6
011 8/1/01 43 33.4 22% 6.7 8.5 21.8 36.8
011 11/13/02 50.4 34.8 30% 16.6 17.4 36.4 25.6
012 Crickett 22Yr Conamara Mare
012 6/25/01 ACTH pre 6 ACTH 013
012 6/4/02 2.9
013 Early 24Yr App Mare
013 4/3/00 ACTH pre 7.6 ACTH post 1.0
013 11/16/01 ACTH pre 4.9 ACTH post 3.0
013 8/10/02 ACTH 187 pg/ml
013 2/22/03 ACTH 175 pg/ml
014 Tess 18Yr TB Mare
014 8/4/99 2.6
014 11/15/00 6.1
014 12/29/00 55.8 27.6 40.7
014 7/26/01 1.4
015 Victor 5 Yr TB Stallion
015 10/22/99 1.7
015 7/26/01 1.6
015 10/20/00 2.5
016 Hammel 20Yr TB Geld
016 10/20/00 1.1
016 12/6/00 2
017 Wilbur 17 Yr App Geld
017 8/1/01 1
017 4/1/02 1.2
018 Blue 19Yr POA Geld
018 7/31/00 55.8 58.5 5.00% 11.9
018 4/23/01 70.4 29.1 59% 15.2 14.6 44.1 243.5
019 Karajean 22Yr Arab Geld
019 10/5/01 1.9
019 5/24/02 1.2
019 6/22/02 66.7 67.4 1% 7.2 9.3 46.1 37.3
019 9/16/02 92.5 45.5 51% 14.4 14.7 29.2 34.9
020 6/22/02 51.5 53.1 3.00% 19.7 17.7 19.2 26.3
021 Karazen xxYr Arab Geld
021 9/16/02 20.2 29.9 32% 14.1 13.3 43.2 82
022 Princess xx Yr YYY HHH
022 10/16/01 72.3 66.5 8.00% 9.2 9.8 50 85.1
022 3/20/03 75.6 53.1 29% 12.9 10.7 16.1 17.2
023 Patrick xxYr YYY HHH
023 3/20/03 68 42 38% 20.4 18.3 8.7 9.9
Macnote: Ingrid: Cyproheptadine is reported to be effective in UK for PPID. In the states here; and in a Clinical Trial by Pennsylvania Veterinary College here in the states it was found to be of no value. I do not know why these contrary results. [maybe the source of the cyproheptadine? ?] There is some value in the low carbohydrate diets used. It seems to me to just control the symptoms and do nothing for the cause of PPID. I am acquainted with one farrier that uses TF in PPID cases and never mentions diet or dry lot maintenance for his clients. ? ? ? ? Some folk in UK use Metformin. That drug “kills off” Adrenal Cortex to lower the Cortisol produced. I don’t adise it ! ! You may want to ask some Veterinarians there about it ! ! Again that seems to be treating the symptom s and not the disease. It is used here in the states for adrenal tumor and Canine Cushing’s. [WHICH IS AN ENTIRELY DIFFERENT DISEASE THAN EQUINE CUSHING’S
Gwenyth Browning Jones Santagate
PENZANCE Equine Integrative Solutions
200 South Street
Douglas, MA 012516